A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation
Identifieur interne : 000091 ( France/Analysis ); précédent : 000090; suivant : 000092A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation
Auteurs : Meike Dittmann [États-Unis] ; Hans-Heinrich Hoffmann [États-Unis] ; Margaret A. Scull [États-Unis] ; Rachel H. Gilmore [États-Unis] ; Kierstin L. Bell [États-Unis] ; Michael Ciancanelli [États-Unis] ; Sam J. Wilson [États-Unis, Royaume-Uni] ; Stefania Crotta [Royaume-Uni] ; Yingpu Yu [États-Unis] ; Brenna Flatley [États-Unis] ; Jing W. Xiao [États-Unis] ; Jean-Laurent Casanova [États-Unis, France] ; Andreas Wack [Royaume-Uni] ; Paul D. Bieniasz [États-Unis] ; Charles M. Rice [États-Unis]Source :
- Cell [ 0092-8674 ] ; 2015.
Abstract
Interferon-stimulated genes (ISGs) act in concert to provide a tight barrier against viruses. Recent studies have shed light on the contribution of individual ISG effectors to the antiviral state, but most have examined those acting on early, intracellular stages of the viral life cycle. Here, we applied an image-based screen to identify ISGs inhibiting late stages of influenza A virus (IAV) infection. We unraveled a directly antiviral function for the gene
Url:
DOI: 10.1016/j.cell.2015.01.040
PubMed: 25679759
PubMed Central: 4328142
Affiliations:
- France, Royaume-Uni, États-Unis
- Écosse, État de New York, Île-de-France
- Glasgow, Paris
- Université de Glasgow
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PMC:4328142Le document en format XML
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Scull</name><affiliation wicri:level="2"><nlm:aff id="aff1">Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Gilmore, Rachel H" sort="Gilmore, Rachel H" uniqKey="Gilmore R" first="Rachel H." last="Gilmore">Rachel H. Gilmore</name><affiliation wicri:level="2"><nlm:aff id="aff1">Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Bell, Kierstin L" sort="Bell, Kierstin L" uniqKey="Bell K" first="Kierstin L." last="Bell">Kierstin L. Bell</name><affiliation wicri:level="2"><nlm:aff id="aff1">Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Ciancanelli, Michael" sort="Ciancanelli, Michael" uniqKey="Ciancanelli M" first="Michael" last="Ciancanelli">Michael Ciancanelli</name><affiliation wicri:level="2"><nlm:aff id="aff2">St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Wilson, Sam J" sort="Wilson, Sam J" uniqKey="Wilson S" first="Sam J." last="Wilson">Sam J. Wilson</name><affiliation wicri:level="2"><nlm:aff id="aff3">Howard Hughes Medical Institute, Laboratory of Retrovirology, Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Howard Hughes Medical Institute, Laboratory of Retrovirology, Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff4">Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK</nlm:aff><orgName type="university">Université de Glasgow</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Crotta, Stefania" sort="Crotta, Stefania" uniqKey="Crotta S" first="Stefania" last="Crotta">Stefania Crotta</name><affiliation wicri:level="1"><nlm:aff id="aff5">Division of Immunoregulation, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Immunoregulation, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA</wicri:regionArea><wicri:noRegion>London NW7 1AA</wicri:noRegion></affiliation></author><author><name sortKey="Yu, Yingpu" sort="Yu, Yingpu" uniqKey="Yu Y" first="Yingpu" last="Yu">Yingpu Yu</name><affiliation wicri:level="2"><nlm:aff id="aff1">Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Flatley, Brenna" sort="Flatley, Brenna" uniqKey="Flatley B" first="Brenna" last="Flatley">Brenna Flatley</name><affiliation wicri:level="2"><nlm:aff id="aff1">Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Xiao, Jing W" sort="Xiao, Jing W" uniqKey="Xiao J" first="Jing W." last="Xiao">Jing W. Xiao</name><affiliation wicri:level="2"><nlm:aff id="aff1">Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name><affiliation wicri:level="2"><nlm:aff id="aff2">St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff6">Howard Hughes Medical Institute, NY 10065, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Howard Hughes Medical Institute, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff7">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Imagine Institute, Inserm, 75015 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Imagine Institute, Inserm, 75015 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff8">Paris Descartes University, 75015 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris Descartes University, 75015 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff9">Pediatric Hematology-Immunology Unit, Necker Hospital for Sick Children, 75015 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Pediatric Hematology-Immunology Unit, Necker Hospital for Sick Children, 75015 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Wack, Andreas" sort="Wack, Andreas" uniqKey="Wack A" first="Andreas" last="Wack">Andreas Wack</name><affiliation wicri:level="1"><nlm:aff id="aff5">Division of Immunoregulation, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Immunoregulation, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA</wicri:regionArea><wicri:noRegion>London NW7 1AA</wicri:noRegion></affiliation></author><author><name sortKey="Bieniasz, Paul D" sort="Bieniasz, Paul D" uniqKey="Bieniasz P" first="Paul D." last="Bieniasz">Paul D. Bieniasz</name><affiliation wicri:level="2"><nlm:aff id="aff3">Howard Hughes Medical Institute, Laboratory of Retrovirology, Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Howard Hughes Medical Institute, Laboratory of Retrovirology, Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Rice, Charles M" sort="Rice, Charles M" uniqKey="Rice C" first="Charles M." last="Rice">Charles M. Rice</name><affiliation wicri:level="2"><nlm:aff id="aff1">Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j">Cell</title><idno type="ISSN">0092-8674</idno><idno type="eISSN">1097-4172</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p>Interferon-stimulated genes (ISGs) act in concert to provide a tight barrier against viruses. Recent studies have shed light on the contribution of individual ISG effectors to the antiviral state, but most have examined those acting on early, intracellular stages of the viral life cycle. Here, we applied an image-based screen to identify ISGs inhibiting late stages of influenza A virus (IAV) infection. We unraveled a directly antiviral function for the gene <italic>SERPINE1</italic>, encoding plasminogen activator inhibitor 1 (PAI-1). By targeting extracellular airway proteases, PAI-1 inhibits IAV glycoprotein cleavage, thereby reducing infectivity of progeny viruses. This was biologically relevant for IAV restriction in vivo. Further, partial PAI-1 deficiency, attributable to a polymorphism in human <italic>SERPINE1</italic>, conferred increased susceptibility to IAV in vitro. Together, our findings reveal that manipulating the extracellular environment to inhibit the last step in a virus life cycle is an important mechanism of the antiviral response.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Beppu, Y" uniqKey="Beppu Y">Y. Beppu</name></author><author><name sortKey="Imamura, Y" uniqKey="Imamura Y">Y. Imamura</name></author><author><name sortKey="Tashiro, M" uniqKey="Tashiro M">M. Tashiro</name></author><author><name sortKey="Towatari, T" uniqKey="Towatari T">T. Towatari</name></author><author><name sortKey="Ariga, H" uniqKey="Ariga H">H. Ariga</name></author><author><name sortKey="Kido, H" uniqKey="Kido H">H. Kido</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berkenpas, M B" uniqKey="Berkenpas M">M.B. Berkenpas</name></author><author><name sortKey="Lawrence, D A" uniqKey="Lawrence D">D.A. 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Klenk</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Écosse</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Glasgow</li><li>Paris</li></settlement><orgName><li>Université de Glasgow</li></orgName></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Dittmann, Meike" sort="Dittmann, Meike" uniqKey="Dittmann M" first="Meike" last="Dittmann">Meike Dittmann</name></region><name sortKey="Bell, Kierstin L" sort="Bell, Kierstin L" uniqKey="Bell K" first="Kierstin L." last="Bell">Kierstin L. Bell</name><name sortKey="Bieniasz, Paul D" sort="Bieniasz, Paul D" uniqKey="Bieniasz P" first="Paul D." last="Bieniasz">Paul D. Bieniasz</name><name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name><name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name><name sortKey="Ciancanelli, Michael" sort="Ciancanelli, Michael" uniqKey="Ciancanelli M" first="Michael" last="Ciancanelli">Michael Ciancanelli</name><name sortKey="Flatley, Brenna" sort="Flatley, Brenna" uniqKey="Flatley B" first="Brenna" last="Flatley">Brenna Flatley</name><name sortKey="Gilmore, Rachel H" sort="Gilmore, Rachel H" uniqKey="Gilmore R" first="Rachel H." last="Gilmore">Rachel H. Gilmore</name><name sortKey="Hoffmann, Hans Heinrich" sort="Hoffmann, Hans Heinrich" uniqKey="Hoffmann H" first="Hans-Heinrich" last="Hoffmann">Hans-Heinrich Hoffmann</name><name sortKey="Rice, Charles M" sort="Rice, Charles M" uniqKey="Rice C" first="Charles M." last="Rice">Charles M. Rice</name><name sortKey="Scull, Margaret A" sort="Scull, Margaret A" uniqKey="Scull M" first="Margaret A." last="Scull">Margaret A. Scull</name><name sortKey="Wilson, Sam J" sort="Wilson, Sam J" uniqKey="Wilson S" first="Sam J." last="Wilson">Sam J. Wilson</name><name sortKey="Xiao, Jing W" sort="Xiao, Jing W" uniqKey="Xiao J" first="Jing W." last="Xiao">Jing W. Xiao</name><name sortKey="Yu, Yingpu" sort="Yu, Yingpu" uniqKey="Yu Y" first="Yingpu" last="Yu">Yingpu Yu</name></country><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Wilson, Sam J" sort="Wilson, Sam J" uniqKey="Wilson S" first="Sam J." last="Wilson">Sam J. Wilson</name></region><name sortKey="Crotta, Stefania" sort="Crotta, Stefania" uniqKey="Crotta S" first="Stefania" last="Crotta">Stefania Crotta</name><name sortKey="Wack, Andreas" sort="Wack, Andreas" uniqKey="Wack A" first="Andreas" last="Wack">Andreas Wack</name></country><country name="France"><region name="Île-de-France"><name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name></region><name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name><name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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